Squeezing out the last 1 nanometer of water: A detailed nanomechanical study

In this study, we present a detailed analysis of the squeeze-out dynamics of nanoconfined water confined between two hydrophilic surfaces measured by small-amplitude dynamic atomic force microscopy (AFM). Explicitly considering the instantaneous tip-surface separation during squeezeout, we confirm the existence of an adsorbed molecular water layer on mica and at least two hydration layers. We also confirm the previous observation of a sharp transition in the viscoelastic response of the nanoconfined water as the compression rate is increased beyond a critical value (previously determined to be about 0.8 nm/s). We find that below the critical value, the tip passes smoothly through the molecular layers of the film, while above the critical speed, the tip encounters "pinning" at separations where the film is able to temporarily order. Pre-ordering of the film is accompanied by increased force fluctuations, which lead to increased damping preceding a peak in the film stiffness once ordering is completed. We analyze the data using both Kelvin-Voigt and Maxwell viscoelastic models. This provides a complementary picture of the viscoelastic response of the confined water film

Optimization of double drive pulse pumping in Ne-like Ge x-ray lasers

Pumping of the Ne-like Ge x-ray laser with two 100 ps duration pulses (a prepulse and main pulse) is investigated using a fluid and atomic physics code coupled to a 3D ray tracing postprocessor code. The modeling predicts the optimum ratio of the irradiance of the two pulses for the maximum x-ray laser output resulting from the balance between the relative lower electron density gradients and wider gain region which is produced with a larger prepulse and the higher peak gain coefficients produced with a small prepulse. With a longer pulse interval between prepulse and main pulse, a relatively lower optimum pulse ratio is found. The threshold irradiance of the main driving pulse with a prepulse required to make an order of magnitude enhancement of laser output compared to irradiation without a prepulse is also found at 3-4x10(13) W/cm(2) for Ne-like Ge. (C) 1998 American Institute of Physics

Efficiency and Stability Issues in the Numerical Computation of Fourier Transforms and Convolutions on the 2-Sphere

Earlier work by Driscoll and Healy has produced an efficient algorithm for computing the Fourier transform of band-limited functions on the sphere. In this paper we present a greatly improved inverse transform, and consequent improved convolution algorithm for such functions. We also discuss implementational considerations and give heuristics for allowing reliable floating point implementations of a slightly modified algorithm at little cost in either theoretical or actual performance. This discussion is supplemented with numerical experiments from our implementation in C on a DecStation 5000. These results give strong indications that the algorithm is both reliable and efficient for a large range of useful problem sizes

Radiation from low-momentum zoom-whirl orbits

We study zoom-whirl behaviour of equal mass, non-spinning black hole binaries in full general relativity. The magnitude of the linear momentum of the initial data is fixed to that of a quasi-circular orbit, and its direction is varied. We find a global maximum in radiated energy for a configuration which completes roughly one orbit. The radiated energy in this case exceeds the value of a quasi-circular binary with the same momentum by 15%. The direction parameter only requires minor tuning for the localization of the maximum. There is non-trivial dependence of the energy radiated on eccentricity (several local maxima and minima). Correlations with orbital dynamics shortly before merger are discussed. While being strongly gauge dependent, these findings are intuitive from a physical point of view and support basic ideas about the efficiency of gravitational radiation from a binary system.Comment: 9 pages, 6 figures, Amaldi8 conference proceedings as publishe

Ground State Wave Function of the Schr\"odinger Equation in a Time-Periodic Potential

Using a generalized transfer matrix method we exactly solve the Schr\"odinger equation in a time periodic potential, with discretized Euclidean space-time. The ground state wave function propagates in space and time with an oscillating soliton-like wave packet and the wave front is wedge shaped. In a statistical mechanics framework our solution represents the partition sum of a directed polymer subjected to a potential layer with alternating (attractive and repulsive) pinning centers.Comment: 11 Pages in LaTeX. A set of 2 PostScript figures available upon request at [email protected] . Physical Review Letter

Built-in field control in alloyed c-plane III-N quantum dots and wells

We investigate the degree to which the built-in electric field can be suppressed by employing polarization-matched barriers in III-N quantum well and dot structures grown along the c axis. Our results show that it is possible to take advantage of the opposite contributions to the built-in potential arising from the different possible combinations of wurtzite GaN, InN, and AlN when alloying the materials. We show that, for a fixed bandgap of the dot/well, optimal alloy compositions can be found that minimize the built-in field across the structure. We discuss and study the impact of different material parameters on the results, including the influence of nonlinear effects in the piezoelectric polarization. Structures grown with unstrained barriers and on GaN epilayers are considered, including discussion of the effects of constraints such as strain limits and alloy miscibility. (C) 2011 American Institute of Physics. [doi:10.1063/1.3563568

Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children

The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit. Seventy-two serum samples were collected at steady state from 12 patients who received piperacillin-tazobactam at 100/12.5 mg/kg of body weight every 8 h infused over 4 h. Population pharmacokinetic analyses were performed using NONMEM, and Monte Carlo simulations were performed to estimate the piperacillin pharmacokinetic profiles for dosing regimens of 80 to 100 mg/kg of the piperacillin component given every 6 to 8 h and infused over 0.5, 3, or 4 h. The probability of target attainment (PTA) for a cumulative percentage of the dosing interval that the drug concentration exceeds the MIC under steady-state pharmacokinetic conditions (TMIC) of\u3e50% was calculated at MICs ranging from 0.25 to 64 mg/liter. The mean ± standard deviation (SD) age, weight, and estimated glomerular filtration rate were 5 ± 3 years, 17 ± 6.2 kg, and 118 ± 41 ml/min/1.73m2, respectively. A one-compartment model with zero-order input and first-order elimination best fit the pharmacokinetic data for both drugs. Weight was significantly associated with piperacillin clearance, and weight and sex were significantly associated with tazobactam clearance. Pharmacokinetic parameters (mean ± SD) for piperacillin and tazobactam were as follows: clearance, 0.22 ± 0.07 and 0.19 ± 0.07 liter/h/kg, respectively; volume of distribution, 0.43 ± 0.16 and 0.37 ± 0.14 liter/kg, respectively. All extended-infusion regimens achieved PTAs of\u3e90% at MICs of/liter. Only the 3-h infusion regimens given every 6 h achieved PTAs of\u3e90% at an MIC of 32 mg/liter. For susceptible bacterial pathogens, piperacillin-tazobactam doses of\u3e80/10 mg/kg given every 8 h and infused over 4 h achieve adequate pharmacodynamic exposures in critically ill children

Phase Separation in One-Dimensional Driven Diffusive Systems

A driven diffusive model of three types of particles that exhibits phase separation on a ring is introduced. The dynamics is local and comprises nearest neighbor exchanges that conserve each of the three species. For the case in which the three densities are equal, it is shown that the model obeys detailed balance. The Hamiltonian governing the steady state distribution in this case is given and is found to have long range asymmetric interactions. The partition sum and bounds on some correlation functions are calculated analytically demonstrating phase separation.Comment: 4 Pages, Revtex, 2 Figures included, Submitted to Physical Review Letter